Open AccessRegulation of Corneal Epithelial Barrier Function by Krüppel-like Transcription Factor 4
Author(s) -
Shivalingappa K. Swamynathan,
Doreswamy Kenchegowda,
Joram Piatigorsky
Publication year - 2011
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.10-6134
Subject(s) - hemidesmosome , klf4 , barrier function , microbiology and biotechnology , basement membrane , corneal epithelium , adherens junction , biology , tight junction , cornea , transcription factor , chemistry , cell , cadherin , biochemistry , sox2 , neuroscience , gene
Previously, the authors showed that Klf4-conditional null (Klf4CN) corneas display epithelial fragility. Here, they investigated the mechanism by which Klf4 regulates corneal epithelial barrier function.