A Novel Role for the Immunoproteasome in Retinal Function | Zendy

Stacy A. Hussong | Zendy; Heidi Roehrich | Zendy; Rebecca J. Kapphahn | Zendy; Marcela Maldonado | Zendy; Machelle T. Pardue | Zendy; Deborah A. Ferrington | Zendy

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A Novel Role for the Immunoproteasome in Retinal Function

Author(s) -

Stacy A. Hussong,

Heidi Roehrich,

Rebecca J. Kapphahn,

Marcela Maldonado,

Machelle T. Pardue,

Deborah A. Ferrington

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.10-6032

Subject(s) - retinal , function (biology) , ophthalmology , chemistry , neuroscience , medicine , microbiology and biotechnology , biology

The immunoproteasome is a proteasome subtype with a well-characterized role in the immune system. The presence of high immunoproteasome concentrations in the photoreceptors and synaptic regions of the immune-privileged retina implies a role in visual transmission. In this study, immunoproteasome knockout (KO) mice lacking either one (lmp7(-/-), L7) or two (lmp7(-/-)/mecl-1(-/-), L7M1) catalytic subunits of the immunoproteasome were used to test the hypothesis that it is essential for the maintenance of normal retinal function.

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