Microarray Analysis of XOPS-mCFP Zebrafish Retina Identifies Genes Associated with Rod Photoreceptor Degeneration and Regeneration | Zendy

Ann C. Morris | Zendy; Marie A. Forbes-Osborne | Zendy; Lakshmi PillaiKastoori | Zendy; James M. Fadool | Zendy

Open Access

Microarray Analysis of XOPS-mCFP Zebrafish Retina Identifies Genes Associated with Rod Photoreceptor Degeneration and Regeneration

Author(s) -

Ann C. Morris,

Marie A. Forbes-Osborne,

Lakshmi PillaiKastoori,

James M. Fadool

Publication year - 2011

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.10-6022

Subject(s) - biology , zebrafish , retinal regeneration , retina , microbiology and biotechnology , regeneration (biology) , microarray analysis techniques , retinal degeneration , gene , gene expression , genetics , neuroscience

XOPS-mCFP transgenic zebrafish experience a continual cycle of rod photoreceptor development and degeneration throughout life, making them a useful model for investigating the molecular determinants of rod photoreceptor regeneration. The purpose of this study was to compare the gene expression profiles of wild-type and XOPS-mCFP retinas and identify genes that may contribute to the regeneration of the rods.

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