Open AccessPotentiating Action of Propofol at GABAAReceptors of Retinal Bipolar Cells
Author(s) -
Yue Lan,
An Xie,
Karol S. Bruzik,
Bente Frølund,
Haohua Qian,
David R. Pepperberg
Publication year - 2011
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.10-5991
Subject(s) - gabaa receptor , propofol , bicuculline , pharmacology , agonist , gaba receptor antagonist , gabaa rho receptor , chemistry , long term potentiation , retina , neuroscience , receptor , biophysics , biology , biochemistry
Propofol (2,6-diisopropyl phenol), a widely used systemic anesthetic, is known to potentiate GABA(A) receptor activity in a number of CNS neurons and to produce changes in electroretinographically recorded responses of the retina. However, little is known about propofol's effects on specific retinal neurons. The authors investigated the action of propofol on GABA-elicited membrane current responses of retinal bipolar cells, which have both GABA(A) and GABA(C) receptors.