Increased Neovascularization in Mice Lacking Tissue Inhibitor of Metalloproteinases-3 | Zendy

Quteba Ebrahem | Zendy; Jian Qi | Zendy; Masahiko Sugimoto | Zendy; Mariya Ali | Zendy; Jonathan E. Sears | Zendy; Alecia Cutler | Zendy; Rama Khokha | Zendy; Amit Vasanji | Zendy; Bela AnandApte | Zendy

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Increased Neovascularization in Mice Lacking Tissue Inhibitor of Metalloproteinases-3

Author(s) -

Quteba Ebrahem,

Jian Qi,

Masahiko Sugimoto,

Mariya Ali,

Jonathan E. Sears,

Alecia Cutler,

Rama Khokha,

Amit Vasanji,

Bela AnandApte

Publication year - 2011

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.10-5899

Subject(s) - angiogenesis , matrix metalloproteinase , choroidal neovascularization , corneal neovascularization , neovascularization , vascular endothelial growth factor , extracellular matrix , biology , tissue inhibitor of metalloproteinase , cancer research , macular degeneration , endocrinology , microbiology and biotechnology , pathology , medicine , ophthalmology , genetics , vegf receptors

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a matrix-bound inhibitor of matrix metalloproteinases (MMPs). The authors have previously determined a novel function of TIMP-3 to inhibit vascular endothelial growth factor (VEGF)-mediated angiogenesis. Here, the authors examined the in vivo angiogenic phenotype of ocular vessels in mice deficient in TIMP-3.

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