TNFα Is Required for Late BRB Breakdown in Diabetic Retinopathy, and Its Inhibition Prevents Leukostasis and Protects Vessels and Neurons from Apoptosis | Zendy

Huang Hu | Zendy; Jarel K. Gandhi | Zendy; Xiufeng Zhong | Zendy; Yanhong Wei | Zendy; Junsong Gong | Zendy; Elia J. Duh | Zendy; Stanley A. Vinores | Zendy

Open Access

TNFα Is Required for Late BRB Breakdown in Diabetic Retinopathy, and Its Inhibition Prevents Leukostasis and Protects Vessels and Neurons from Apoptosis

Author(s) -

Huang Hu,

Jarel K. Gandhi,

Xiufeng Zhong,

Yanhong Wei,

Junsong Gong,

Elia J. Duh,

Stanley A. Vinores

Publication year - 2011

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.10-5768

Subject(s) - leukostasis , inflammation , apoptosis , tumor necrosis factor alpha , diabetic retinopathy , medicine , diabetes mellitus , retinal , streptozotocin , tunel assay , retina , immunology , endocrinology , biology , ophthalmology , neuroscience , biochemistry , immunohistochemistry

Blood-retinal barrier [BRB] breakdown, characteristic of diabetic retinopathy (DR), is believed to depend on inflammation and apoptosis. Retinal inflammation is almost completely suppressed in the absence of TNFα, which is also associated with apoptosis. This study was conducted to determine the role of TNFα in these diabetic complications.

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