Spontaneous Bacterial Keratitis in CD36 Knockout Mice | Zendy

Julia Klocke | Zendy; Rita N. Bárcia | Zendy; Susan R. Heimer | Zendy; Elke Cario | Zendy; James D. Zieske | Zendy; Michael S. Gilmore | Zendy; Bruce R. Ksander | Zendy; Meredith S. Gregory | Zendy

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Spontaneous Bacterial Keratitis in CD36 Knockout Mice

Author(s) -

Julia Klocke,

Rita N. Bárcia,

Susan R. Heimer,

Elke Cario,

James D. Zieske,

Michael S. Gilmore,

Bruce R. Ksander,

Meredith S. Gregory

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.10-5566

Subject(s) - corneal epithelium , cd36 , mucin , biology , microbiology and biotechnology , tlr2 , keratitis , cornea , immunology , receptor , immune system , innate immune system , biochemistry , genetics , neuroscience

CD36 is a Class B scavenger receptor that is constitutively expressed in the corneal epithelium and has been implicated in many homeostatic functions, including the homeostasis of the epidermal barrier. The aim of this study is to determine (1) whether CD36 is required for the maintenance of the corneal epithelial barrier to infection, and (2) whether CD36-deficient mice present with an increased susceptibility to bacterial keratitis.

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