Evaluation of AAV-Mediated Expression of Chop2-GFP in the Marmoset Retina | Zendy

Elena Ivanova | Zendy; Grace-Soon Hwang | Zendy; Zhuo-Hua Pan | Zendy; David Troilo | Zendy

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Evaluation of AAV-Mediated Expression of Chop2-GFP in the Marmoset Retina

Author(s) -

Elena Ivanova,

Grace-Soon Hwang,

Zhuo-Hua Pan,

David Troilo

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.10-5389

Subject(s) - marmoset , retina , green fluorescent protein , microbiology and biotechnology , biology , chemistry , neuroscience , genetics , ecology , gene

Converting inner retinal neurons to photosensitive cells by expressing channelrhodopsin-2 (ChR2) offers a novel approach for treating blindness caused by retinal degenerative diseases. In the present study, the recombinant adeno-associated virus serotype 2 (rAAV2)-mediated expression and function of a fusion construct of channelopsin-2 (Chop2) and green fluorescent protein (GFP) (Chop2-GFP) were evaluated in the inner retinal neurons in the common marmoset Callithrix jacchus.

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