Diabetes-Induced Inhibition of Voltage-Dependent Calcium Channels in the Retinal Microvasculature: Role of Spermine | Zendy

Kenji Matsushita | Zendy; Masanori Fukumoto | Zendy; Takatoshi Kobayashi | Zendy; Masato Kobayashi | Zendy; Eisuke Ishizaki | Zendy; Masahiro Minami | Zendy; Kozo Katsumura | Zendy; Sophie D. Liao | Zendy; David M. Wu | Zendy; Ting Zhang | Zendy; Donald G. Puro | Zendy

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Diabetes-Induced Inhibition of Voltage-Dependent Calcium Channels in the Retinal Microvasculature: Role of Spermine

Author(s) -

Kenji Matsushita,

Masanori Fukumoto,

Takatoshi Kobayashi,

Masato Kobayashi,

Eisuke Ishizaki,

Masahiro Minami,

Kozo Katsumura,

Sophie D. Liao,

David M. Wu,

Ting Zhang,

Donald G. Puro

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.10-5377

Subject(s) - retina , retinal , microbiology and biotechnology , calcium , voltage dependent calcium channel , spermine , biology , biophysics , chemistry , anatomy , medicine , neuroscience , biochemistry , enzyme

Although decentralized control of blood flow is particularly important in the retina, knowledge of the functional organization of the retinal microvasculature is limited. Here, the authors characterized the distribution and regulation of L-type voltage-dependent calcium channels (VDCCs) within the most decentralized operational complex of the retinal vasculature--the feeder vessel/capillary unit--which consists of a capillary network plus the vessel linking it with a myocyte-encircled arteriole.

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