Complement Component C5a Activates ICAM-1 Expression on Human Choroidal Endothelial Cells | Zendy

Jessica M. Skeie | Zendy; John H. Fingert | Zendy; Stephen R. Russell | Zendy; Edwin M. Stone | Zendy; Robert F. Mullins | Zendy

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Complement Component C5a Activates ICAM-1 Expression on Human Choroidal Endothelial Cells

Author(s) -

Jessica M. Skeie,

John H. Fingert,

Stephen R. Russell,

Edwin M. Stone,

Robert F. Mullins

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.10-5322

Subject(s) - complement system , choroid , biology , immunohistochemistry , endothelium , endothelial stem cell , macular degeneration , immunology , pathology , medicine , retina , endocrinology , antibody , genetics , ophthalmology , in vitro , neuroscience

The complement system plays a crucial role in the progression of age-related macular degeneration (AMD). In this study, the authors sought to evaluate the pathophysiologic roles of complement components C3a and C5a in the human choroid in AMD.

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