Cell Proliferation and Interleukin-6–Type Cytokine Signaling Are Implicated by Gene Expression Responses in Early Optic Nerve Head Injury in Rat Glaucoma | Zendy

Elaine C. Johnson | Zendy; Thomas A. Doser | Zendy; William O. Cepurna | Zendy; J. A. Dyck | Zendy; Lijun Jia | Zendy; Ying Guo | Zendy; Wendi S. Lambert | Zendy; John C. Morrison | Zendy

Open Access

Cell Proliferation and Interleukin-6–Type Cytokine Signaling Are Implicated by Gene Expression Responses in Early Optic Nerve Head Injury in Rat Glaucoma

Author(s) -

Elaine C. Johnson,

Thomas A. Doser,

William O. Cepurna,

J. A. Dyck,

Lijun Jia,

Ying Guo,

Wendi S. Lambert,

John C. Morrison

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.10-5317

Subject(s) - optic nerve , biology , gene expression , glial fibrillary acidic protein , pathology , medicine , immunology , anatomy , gene , immunohistochemistry , biochemistry

In glaucoma, the optic nerve head (ONH) is the principal site of initial axonal injury, and elevated intraocular pressure (IOP) is the predominant risk factor. However, the initial responses of the ONH to elevated IOP are unknown. Here the authors use a rat glaucoma model to characterize ONH gene expression changes associated with early optic nerve injury.

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