Establishment of a New Animal Model of Focal Subretinal Fibrosis That Resembles Disciform Lesion in Advanced Age-Related Macular Degeneration | Zendy

YoungJoon Jo | Zendy; KohHei Sonoda | Zendy; Yuji Oshima | Zendy; Atsunobu Takeda | Zendy; Ri-ichiro Kohno | Zendy; Jun Yamada | Zendy; Junji Hamuro | Zendy; Yang Yang | Zendy; Shoji Notomi | Zendy; Toshio Hisatomi | Zendy; Tatsuro Ishibashi | Zendy

Open Access

Establishment of a New Animal Model of Focal Subretinal Fibrosis That Resembles Disciform Lesion in Advanced Age-Related Macular Degeneration

Author(s) -

YoungJoon Jo,

KohHei Sonoda,

Yuji Oshima,

Atsunobu Takeda,

Ri-ichiro Kohno,

Jun Yamada,

Junji Hamuro,

Yang Yang,

Shoji Notomi,

Toshio Hisatomi,

Tatsuro Ishibashi

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.10-5189

Subject(s) - pathology , fibrosis , glial fibrillary acidic protein , retina , macular degeneration , retinal , retinal pigment epithelium , lesion , macrophage , masson's trichrome stain , medicine , anatomy , biology , immunohistochemistry , in vitro , ophthalmology , biochemistry , neuroscience

Subretinal fibrosis causes damage to visual acuity, especially if the lesion is in the macula, as is frequently observed in advanced age-related macular degeneration. Exudate leukocytes form abnormal vessels that initiate regional inflammation accompanied with local glial proliferation and matrix production. The purpose of this study was to establish an animal model of focal subretinal fibrosis.

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