A Subretinal Matrigel Rat Choroidal Neovascularization (CNV) Model and Inhibition of CNV and Associated Inflammation and Fibrosis by VEGF Trap | Zendy

Jingtai Cao | Zendy; Lian Zhao | Zendy; Yiwen Li | Zendy; Yang Liu | Zendy; Weihong Xiao | Zendy; Ying Song | Zendy; Lingyu Luo | Zendy; Deqiang Huang | Zendy; George D. Yancopoulos | Zendy; Stanley J. Wiegand | Zendy; Rong Wen | Zendy

Open Access

A Subretinal Matrigel Rat Choroidal Neovascularization (CNV) Model and Inhibition of CNV and Associated Inflammation and Fibrosis by VEGF Trap

Author(s) -

Jingtai Cao,

Lian Zhao,

Yiwen Li,

Yang Liu,

Weihong Xiao,

Ying Song,

Lingyu Luo,

Deqiang Huang,

George D. Yancopoulos,

Stanley J. Wiegand,

Rong Wen

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.09-4956

Subject(s) - choroidal neovascularization , matrigel , fibrosis , vascular endothelial growth factor , medicine , macular degeneration , inflammation , growth factor , pathology , cancer research , angiogenesis , ophthalmology , immunology , receptor , vegf receptors

The exudative, or the wet form of age-related macular degeneration (AMD) is characterized by choroidal neovascularization (CNV). A subretinal Matrigel (BD Biosciences, Bedford MA) model of CNV is described here, along with the effects of vascular endothelial growth factor (VEGF) neutralization on the development of CNV and associated inflammation and fibrosis.

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