7-Ketocholesterol–Induced Inflammation: Involvement of Multiple Kinase Signaling Pathways via NFκB but Independently of Reactive Oxygen Species Formation | Zendy

Ignacio M. Larráyoz | Zendy; Jiahn-Dar Huang | Zendy; Jung Wha Lee | Zendy; Iranzu Pascual | Zendy; Ignacio R. Rodríguez | Zendy

Open Access

7-Ketocholesterol–Induced Inflammation: Involvement of Multiple Kinase Signaling Pathways via NFκB but Independently of Reactive Oxygen Species Formation

Author(s) -

Ignacio M. Larráyoz,

Jiahn-Dar Huang,

Jung Wha Lee,

Iranzu Pascual,

Ignacio R. Rodríguez

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.09-4854

Subject(s) - mapk/erk pathway , cytokine , microbiology and biotechnology , p38 mitogen activated protein kinases , chemistry , signal transduction , protein kinase b , kinase , pi3k/akt/mtor pathway , protein kinase c , proinflammatory cytokine , nf κb , phosphorylation , inflammation , biology , immunology

7-Ketocholesterol (7KCh) accumulates in oxidized lipoprotein deposits and is known to be involved in macrophage foam cell formation and atherosclerosis. 7-KCh is present in the primate retina and is associated with oxidized lipoprotein deposits located in the choriocapillaris, Bruch's membrane, and retinal pigment epithelium (RPE). 7-KCh can also be formed in the retina as a consequence of light-induced iron release. The purpose of this study was to examine the signaling pathways involved in the 7KCh-mediated inflammatory response focusing on three cytokines, VEGF, IL-6, and IL-8.

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