Molecular Mechanism of Proinflammatory Cytokine-Mediated Squamous Metaplasia in Human Corneal Epithelial Cells | Zendy

Shimin Li | Zendy; Marianne Gallup | Zendy; YingTing Chen | Zendy; Nancy A. McNamara | Zendy

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Molecular Mechanism of Proinflammatory Cytokine-Mediated Squamous Metaplasia in Human Corneal Epithelial Cells

Author(s) -

Shimin Li,

Marianne Gallup,

YingTing Chen,

Nancy A. McNamara

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.09-4677

Subject(s) - proinflammatory cytokine , microbiology and biotechnology , mapk/erk pathway , p38 mitogen activated protein kinases , biology , creb , chemistry , signal transduction , gene , transcription factor , immunology , biochemistry , inflammation

The cornified envelope protein small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia. Proinflammatory cytokines IL-1beta and IFN-gamma are potent inducers of ocular surface keratinization and SPRR1B expression. Here the molecular mechanisms controlling SPRR1B gene expression in response to IL-1beta and IFN-gamma are elucidated.

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