Intracellular Thiol Redox Status Regulates Lymphangiogenesis and Dictates Corneal Limbal Graft Survival | Zendy

Akiko Fukumoto | Zendy; Kazuichi Maruyama | Zendy; Tony G. Walsh | Zendy; Kentaro Kajiya | Zendy; Junji Hamuro | Zendy; Patricia A. D’Amore | Zendy; Shigeru Kinoshita | Zendy

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Intracellular Thiol Redox Status Regulates Lymphangiogenesis and Dictates Corneal Limbal Graft Survival

Author(s) -

Akiko Fukumoto,

Kazuichi Maruyama,

Tony G. Walsh,

Kentaro Kajiya,

Junji Hamuro,

Patricia A. D’Amore,

Shigeru Kinoshita

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.09-4618

Subject(s) - lymphangiogenesis , intracellular , redox , microbiology and biotechnology , thiol , chemistry , medicine , biology , biochemistry , metastasis , cancer , organic chemistry

Compounds regulating intracellular thiol redox status, such as N,N-diacetyl-L-cystine dimethylester (NM(2)), were shown to prolong corneal graft survival in a penetrating keratoplasty (PKP) model. However, the effect of NM(2) on hemangiogenesis and lymphangiogenesis has not been investigated. The effect of manipulating ambient thiol redox status on riskier (higher rejection rate) transplantation models, such as limbal graft survival and hemangiogenesis and lymphangiogenesis in a corneal suture model, were investigated.

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