Open AccessResponses of Cultured Human Keratocytes and Myofibroblasts to Ethyl Pyruvate: A Microarray Analysis of Gene Expression
Author(s) -
S. Harvey,
Emily Guerriero,
Nahthai Charukamnoetkanok,
Jordan Piluek,
Joel S. Schuman,
Nirmala SundarRaj
Publication year - 2010
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.09-4498
Subject(s) - myofibroblast , stromal cell , downregulation and upregulation , microarray analysis techniques , phenotype , gene , biology , microbiology and biotechnology , gene expression , wound healing , transforming growth factor , oxidative stress , cancer research , pathology , immunology , genetics , endocrinology , fibrosis , medicine
Ethyl pyruvate (EP) has pharmacologic effects that remediate cellular stress. In the organ-cultured murine lens, EP ameliorates oxidative stress, and in a rat cataract model, it attenuates cataract formation. However, corneal responses to EP have not been elucidated. In this study, the potential of EP as a therapeutic agent in corneal wound healing was determined by examining its effects on the transition of quiescent corneal stromal keratocytes into contractile myofibroblasts.