Apolipoprotein E Genotype Is Associated with Macular Pigment Optical Density | Zendy

Edward Loane | Zendy; Gareth J. McKay | Zendy; John M. Nolan | Zendy; Stephen Beatty | Zendy

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Apolipoprotein E Genotype Is Associated with Macular Pigment Optical Density

Author(s) -

Edward Loane,

Gareth J. McKay,

John M. Nolan,

Stephen Beatty

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.09-4397

Subject(s) - zeaxanthin , macular degeneration , genotype , apolipoprotein e , lutein , genotyping , medicine , biology , genetics , ophthalmology , carotenoid , biochemistry , gene , disease

Age-related macular degeneration (AMD) is the most common cause of blindness in older people in developed countries, and risk factors for this condition may be classified as genetic and environmental. Apolipoprotein E is putatively involved in the transport of the macular pigment (MP) carotenoids lutein (L) and zeaxanthin (Z) in serum and may also influence retinal capture of these compounds. This study was designed to investigate the relationship between macular pigment optical density (MPOD) and ApoE genotype.

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