Deactivation Mechanisms of Rod Phototransduction: The Cogan Lecture | Zendy

Marie E. Burns | Zendy

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Deactivation Mechanisms of Rod Phototransduction: The Cogan Lecture

Author(s) -

Marie E. Burns

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.09-4366

Subject(s) - visual phototransduction , limiting , rod , cascade , biophysics , absorption (acoustics) , microbiology and biotechnology , retina , neuroscience , biology , optics , chemistry , physics , medicine , mechanical engineering , alternative medicine , pathology , chromatography , engineering

The absorption of photons in rods and cones of the retina activate homologous biochemical signaling cascades that lead to the electrical changes that subserve the first steps in vision. Persistent activity of the cascade interferes with the ability of the photoreceptor to signal the absorption of subsequent photons, ultimately limiting the photoreceptor's sensitivity and temporal resolution. This article summarizes recent work on transgenic and knockout mouse rods that has revealed the deactivation mechanisms essential for normal response recovery and how each of these processes contributes to the overall time course of the flash response of rods.

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