Open AccessAn Ecological Correlation Study of Late Age-Related Macular Degeneration and the Complement Factor H Y402H Polymorphism
Author(s) -
Bareng A. S. yane,
Dorothea Nitsch,
John C. Whittaker,
Reecha Sofat,
Liam Smeeth,
Usha Chakravarthy,
Astrid Fletcher
Publication year - 2010
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.09-4228
Subject(s) - macular degeneration , factor h , correlation , polymorphism (computer science) , complement (music) , biology , genetics , medicine , ophthalmology , allele , complement system , gene , mathematics , antibody , geometry , complementation , phenotype
To investigate whether variation in the distribution of the risk allele frequency of the Y402H single-nucleotide polymorphism (SNP) across various ethnicities and geographic regions reflects differences in the prevalence of late age-related macular degeneration (AMD) in those ethnicities.