Soluble and Mature Amyloid Fibrils in Drusen Deposits | Zendy

J. Mario Isas | Zendy; Volker Luibl | Zendy; Lincoln V. Johnson | Zendy; Rakez Kayed | Zendy; Ronald Wetzel | Zendy; Charles Glabe | Zendy; Ralf Langen | Zendy; Jeannie Chen | Zendy

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Soluble and Mature Amyloid Fibrils in Drusen Deposits

Author(s) -

J. Mario Isas,

Volker Luibl,

Lincoln V. Johnson,

Rakez Kayed,

Ronald Wetzel,

Charles Glabe,

Ralf Langen,

Jeannie Chen

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.09-4207

Subject(s) - drusen , fibril , amyloid (mycology) , chemistry , antibody , biophysics , monoclonal antibody , pathology , retinal , biochemistry , biology , immunology , medicine , inorganic chemistry

Drusen are a hallmark of eyes affected by age-related macular degeneration. In previous study, a conformational-specific antibody showed drusen to contain nonfibrillar amyloid structures. The current study was undertaken to assess the presence of additional amyloid structures in drusen.

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