Protection of Retinal Ganglion Cells by Caspase Substrate-Binding Peptide IQACRG fromN-Methyl-d-Aspartate Receptor-Mediated Excitotoxicity | Zendy

Masaaki Seki | Zendy; Walid Soussou | Zendy; Shin-ichi Manabe | Zendy; Stuart A. Lipton | Zendy

Open Access

Protection of Retinal Ganglion Cells by Caspase Substrate-Binding Peptide IQACRG fromN-Methyl-d-Aspartate Receptor-Mediated Excitotoxicity

Author(s) -

Masaaki Seki,

Walid Soussou,

Shin-ichi Manabe,

Stuart A. Lipton

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.09-4102

Subject(s) - neuroprotection , excitotoxicity , nmda receptor , in vivo , retinal ganglion cell , retina , pharmacology , ex vivo , caspase 3 , microbiology and biotechnology , biology , chemistry , programmed cell death , biochemistry , neuroscience , apoptosis , receptor

This study investigated whether the enzymatically inactive caspase mimetic IQACRG protects rat retinal ganglion cells (RGCs) from excitotoxic insults. Minimally invasive delivery of the peptide to the retina was explored, and the mechanisms of neuroprotection were elucidated.

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