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This study investigated whether the enzymatically inactive caspase mimetic IQACRG protects rat retinal ganglion cells (RGCs) from excitotoxic insults. Minimally invasive delivery of the peptide to the retina was explored, and the mechanisms of neuroprotection were elucidated.

investigative ophthalmology and visual science

Protection of Retinal Ganglion Cells by Caspase Substrate-Binding Peptide IQACRG from<i>N</i>-Methyl-<scp>d</scp>-Aspartate Receptor-Mediated Excitotoxicity

Protection of Retinal Ganglion Cells by Caspase Substrate-Binding Peptide IQACRG fromN-Methyl-d-Aspartate Receptor-Mediated Excitotoxicity