Role of CCR7 in Facilitating Direct Allosensitization and Regulatory T-Cell Function in High-Risk Corneal Transplantation | Zendy

Yiping Jin | Zendy; Sunil K. Chauhan | Zendy; Daniel R. Saban | Zendy; Reza Dana | Zendy

Open Access

Role of CCR7 in Facilitating Direct Allosensitization and Regulatory T-Cell Function in High-Risk Corneal Transplantation

Author(s) -

Yiping Jin,

Sunil K. Chauhan,

Daniel R. Saban,

Reza Dana

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.09-3952

Subject(s) - c c chemokine receptor type 7 , function (biology) , regulatory t cell , medicine , cancer research , immunology , microbiology and biotechnology , t cell , biology , immune system , il 2 receptor , chemokine , chemokine receptor

Chemokine receptor 7 (CCR7) is a key homing molecule for immune cell trafficking, including corneal antigen-presenting cell (APC) migration from the inflamed cornea to draining lymph nodes (LNs). Here, the authors investigated the effect of CCR7-facilitated donor APC trafficking on allosensitization, regulatory T-cell (Treg) function, and graft survival in corneal transplantation.

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