The Microbead Occlusion Model: A Paradigm for Induced Ocular Hypertension in Rats and Mice | Zendy

Rebecca M. Sappington | Zendy; Brian J. Carlson | Zendy; Samuel D. Crish | Zendy; David J. Calkins | Zendy

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The Microbead Occlusion Model: A Paradigm for Induced Ocular Hypertension in Rats and Mice

Author(s) -

Rebecca M. Sappington,

Brian J. Carlson,

Samuel D. Crish,

David J. Calkins

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.09-3947

Subject(s) - intraocular pressure , ocular hypertension , microbead (research) , glaucoma , medicine , saline , isotonic saline , ophthalmology , animal model , anesthesia , chemistry , biochemistry

Elevated intraocular pressure (IOP) is an important risk factor for glaucoma. Animal models often involve techniques for IOP elevation that are surgically invasive. Here the authors describe a novel and relatively simple method for inducing a highly consistent, modest, and repeatable elevation in IOP for rats and mice.

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