Inhibition of Chemokine Receptor Expression on Uveal Melanomas by CXCR4 siRNA and Its Effect on Uveal Melanoma Liver Metastases | Zendy

Haochuan Li | Zendy; Wanhua Yang | Zendy; Peter W. Chen | Zendy; Hassan Alizadeh | Zendy; Jérry Y. Niederkorn | Zendy

Open Access

Inhibition of Chemokine Receptor Expression on Uveal Melanomas by CXCR4 siRNA and Its Effect on Uveal Melanoma Liver Metastases

Author(s) -

Haochuan Li,

Wanhua Yang,

Peter W. Chen,

Hassan Alizadeh,

Jérry Y. Niederkorn

Publication year - 2009

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.09-3804

Subject(s) - melanoma , transfection , chemokine receptor , cancer research , chemokine , cxcr4 , cxc chemokine receptors , micrometastasis , metastasis , interleukin 8 , gene knockdown , cell culture , medicine , receptor , biology , pathology , immunology , cytokine , cancer , genetics

To determine whether blocking the expression of the chemokine receptor CXCR4 using siRNA inhibits chemotactic responses of human uveal melanoma cells to liver-derived factors and prevents liver metastases.

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