Mechanisms of Corneal Tissue Cross-linking in Response to Treatment with Topical Riboflavin and Long-Wavelength Ultraviolet Radiation (UVA) | Zendy

A. Scott McCall | Zendy; Stefan Kraft | Zendy; Henry F. Edelhauser | Zendy; George W. Kidder | Zendy; Richard Lundquist | Zendy; Helen E. Bradshaw | Zendy; Zinaida Dedeic | Zendy; Megan J. C. Dionne | Zendy; Ethan M. Clement | Zendy; Gary W. Conrad | Zendy

Open Access

Mechanisms of Corneal Tissue Cross-linking in Response to Treatment with Topical Riboflavin and Long-Wavelength Ultraviolet Radiation (UVA)

Author(s) -

A. Scott McCall,

Stefan Kraft,

Henry F. Edelhauser,

George W. Kidder,

Richard Lundquist,

Helen E. Bradshaw,

Zinaida Dedeic,

Megan J. C. Dionne,

Ethan M. Clement,

Gary W. Conrad

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.09-3738

Subject(s) - chemistry , singlet oxygen , biophysics , stroma , cornea , keratoconus , ultimate tensile strength , photochemistry , oxygen , ophthalmology , materials science , organic chemistry , immunology , medicine , biology , immunohistochemistry , metallurgy

Treatment of de-epithelialized human corneas with riboflavin (RF) + long-wavelength ultraviolet light (UVA; RFUVA) increases corneal stroma tensile strength significantly. RFUVA treatment retards the progression of keratoconus, perhaps by cross-linking of collagen molecules, but exact molecular mechanisms remain unknown. Research described here tested possible chemical mechanisms of cross-linking.

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