Open AccessEffects of Elevated Thyroid Hormone on Adult Rabbit Extraocular Muscles
Author(s) -
Andrew R. Harrison,
Michael S. Lee,
Linda K. McLoon
Publication year - 2010
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.09-3681
Subject(s) - myod , thyroid , medicine , endocrinology , biology , hormone , myocyte , extraocular muscles , myosin , population , anatomy , myogenesis , microbiology and biotechnology , environmental health
Human extraocular muscles (EOM) are preferentially susceptible to thyroid eye disease. Although the specific cause of this autoimmune disorder is unknown, it is often associated with elevated thyroid hormone levels. Thus, the effect of elevated thyroid hormone levels on cross-sectional area, myofiber size, satellite cells, and myosin heavy chain (MyHC) isoform expression was examined in adult rabbit EOMs, to determine how elevated thyroid hormone alters EOM biology.