Axonal/Glial Upregulation of EphB/ephrin-B Signaling in Mouse Experimental Ocular Hypertension | Zendy

Christine Fu | Zendy; Tony Tran | Zendy; David W. Sretavan | Zendy

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Axonal/Glial Upregulation of EphB/ephrin-B Signaling in Mouse Experimental Ocular Hypertension

Author(s) -

Christine Fu,

Tony Tran,

David W. Sretavan

Publication year - 2010

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.09-3579

Subject(s) - ephrin , downregulation and upregulation , optic nerve , erythropoietin producing hepatocellular (eph) receptor , retinal ganglion cell , axon , retina , ocular hypertension , biology , signal transduction , microbiology and biotechnology , neuroscience , glaucoma , biochemistry , gene , receptor tyrosine kinase

To use a laser-induced ocular hypertension (LIOH) mouse model to examine the optic nerve head (ONH) expression of EphB/ephrin-B, previously shown to be upregulated in glaucomatous DBA/2J mice. To relate ephrin-B reverse signaling with states of axonal response to disease.

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