Stromal Edema inKlf4Conditional Null Mouse Cornea Is Associated with Altered Collagen Fibril Organization and Reduced Proteoglycans | Zendy

Robert D. Young | Zendy; Shivalingappa K. Swamynathan | Zendy; Craig Boote | Zendy; Mary Mann | Zendy; Andrew J. Quantock | Zendy; Joram Piatigorsky | Zendy; James L. Funderburgh | Zendy; Keith M. Meek | Zendy

Open Access

Stromal Edema inKlf4Conditional Null Mouse Cornea Is Associated with Altered Collagen Fibril Organization and Reduced Proteoglycans

Author(s) -

Robert D. Young,

Shivalingappa K. Swamynathan,

Craig Boote,

Mary Mann,

Andrew J. Quantock,

Joram Piatigorsky,

James L. Funderburgh,

Keith M. Meek

Publication year - 2009

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.09-3561

Subject(s) - cornea , lumican , stromal cell , stroma , chemistry , proteoglycan , fibril , immunogold labelling , anatomy , electron microscope , extracellular matrix , collagen fibril , biophysics , pathology , microbiology and biotechnology , biology , decorin , biochemistry , ultrastructure , immunohistochemistry , optics , medicine , physics , neuroscience

Klf4, one of the highly expressed transcription factors in the mouse cornea, plays an important role in maturation and maintenance of the ocular surface. In this study, the structure and proteoglycan composition of the Klf4 conditional null (Klf4CN) corneal stroma was investigated, to further characterize the previously reported Klf4CN stromal edema.

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