Open AccessAge-Related Changes in the Spatial Distribution of Human Lens α-Crystallin Products by MALDI Imaging Mass Spectrometry
Author(s) -
Angus C. Grey,
Kevin L. Schey
Publication year - 2009
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.09-3522
Subject(s) - crystallin , mass spectrometry , mass spectrometry imaging , lens (geology) , maldi imaging , chemistry , chromatography , matrix assisted laser desorption/ionization , optics , physics , biochemistry , organic chemistry , adsorption , desorption
To develop a protocol for MALDI (matrix-assisted laser desorption ionization) imaging mass spectrometry for mapping the distributions of alpha-crystallin and its modified forms in human lens tissue as a function of lens age and cataract.