Inhibition of Human Scleral Fibroblast Cell Attachment to Collagen Type I by TGFBIp | Zendy

Lilian Shelton | Zendy; Jody A. Rada | Zendy

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Inhibition of Human Scleral Fibroblast Cell Attachment to Collagen Type I by TGFBIp

Author(s) -

Lilian Shelton,

Jody A. Rada

Publication year - 2009

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.09-3460

Subject(s) - fibroblast , tgfbi , microbiology and biotechnology , extracellular matrix , type i collagen , integrin , chemistry , collagen, type i, alpha 1 , cell , biology , biochemistry , in vitro , endocrinology

Transforming growth factor beta-induced protein (TGFBIp; 68 kDa) is a secreted extracellular matrix (ECM) protein that has been demonstrated to regulate cell attachment in a variety of cell types. The sclera synthesizes and secretes TGFBIp, which may function to facilitate scleral ECM remodeling events associated with myopia development. Here the authors report that human scleral fibroblasts (HSFs) express TGFBI and that its protein product, TGFBIp, mediates an effect on cell attachment.

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