FoxC1Is Essential for Vascular Basement Membrane Integrity and Hyaloid Vessel Morphogenesis | Zendy

Jonathan M. Skarie | Zendy; Brian A. Link | Zendy

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FoxC1Is Essential for Vascular Basement Membrane Integrity and Hyaloid Vessel Morphogenesis

Author(s) -

Jonathan M. Skarie,

Brian A. Link

Publication year - 2009

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.09-3447

Subject(s) - zebrafish , biology , basement membrane , morphogenesis , microbiology and biotechnology , morpholino , gene knockdown , glaucoma , laminin , pathology , anatomy , gene , genetics , medicine , extracellular matrix , neuroscience

Alterations in FOXC1 dosage lead to a spectrum of highly penetrant, ocular anterior segment dysgenesis phenotypes. The most serious outcome is the development of glaucoma, which occurs in 50% to 75% of patients. Therefore, the need to identify specific pathways and genes that interact with FOXC1 to promote glaucoma is great. In this study, the authors investigated the loss of foxC1 in the zebrafish to characterize phenotypes and gene interactions that may impact glaucoma pathogenesis.

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