Sphingosine-1-Phosphate Is a Key Regulator of Proliferation and Differentiation in Retina Photoreceptors | Zendy

Gisela E. Miranda | Zendy; Carolina E. Abrahan | Zendy; Luis E. Politi | Zendy; Nora P. Rotstein | Zendy

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Sphingosine-1-Phosphate Is a Key Regulator of Proliferation and Differentiation in Retina Photoreceptors

Author(s) -

Gisela E. Miranda,

Carolina E. Abrahan,

Luis E. Politi,

Nora P. Rotstein

Publication year - 2009

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.09-3388

Subject(s) - microbiology and biotechnology , glial cell line derived neurotrophic factor , biology , sphingosine kinase , sphingosine 1 phosphate , sphingosine , neurotrophic factors , biochemistry , receptor

Identifying the cues required for the survival and development of photoreceptors is essential for treating retinal neurodegeneration. The authors previously established that glial-derived neurotrophic factor (GDNF) stimulates proliferation and that docosahexaenoic acid (DHA) promotes photoreceptor survival and differentiation. Later findings that ceramide triggers photoreceptor apoptosis suggested sphingolipids might also control photoreceptor development. The present study investigated whether sphingosine-1-phophate (S1P), which promotes survival and differentiation in several cell types, regulates photoreceptor proliferation and differentiation and whether it is a mediator in GDNF and DHA effects.

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