Open AccessRole of IL-6 in Angiotensin II–Induced Retinal Vascular Inflammation
Author(s) -
Modesto Rojas,
Wenbo Zhang,
Dexter L. Lee,
Maritza J. Romero,
Doan T. Nguyen,
Mohamed AlShabrawey,
Nai Tse Tsai,
Gregory I. Liou,
Michael Brands,
Robert W. Caldwell,
Ruth B. Caldwell
Publication year - 2010
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.09-3375
Subject(s) - angiotensin ii , leukostasis , retinal , proinflammatory cytokine , nadph oxidase , inflammation , chemistry , endocrinology , medicine , biology , immunology , biochemistry , oxidative stress , blood pressure
The production of proinflammatory cytokines has been shown to play a critical role in a variety of retinal vascular diseases. Angiotensin II and VEGF have been implicated in the initiation of vascular inflammation and retinal vascular disease. However, detailed mechanisms of this process and interactions between inflammatory agonists and angiotensin II in promoting retinopathy are poorly understood. The present study was an investigation of the role of interleukin (IL)-6 in angiotensin II-induced retinopathy.