Open AccessNuclear Ferritin: A Ferritoid-Ferritin Complex in Corneal Epithelial Cells
Author(s) -
Maria Nurminskaya,
Christopher J. Talbot,
Dmitry I. Nurminsky,
Kelly E. Beazley,
Thomas F. Linsenmayer
Publication year - 2009
Publication title -
investigative ophthalmology and visual science
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.08-3170
Subject(s) - ferritin , chemistry , microbiology and biotechnology , biology , biochemistry
Ferritin is an iron storage protein that is generally cytoplasmic. However, in embryonic avian corneal epithelial (CE) cells, the authors previously observed that the ferritin was predominantly nuclear. They also obtained evidence that this ferritin protects DNA from oxidative damage by UV light and hydrogen peroxide and that the nuclear localization involves a tissue-specific nuclear transporter, termed ferritoid. In the present investigation, the authors have determined additional properties of the nuclear ferritoid-ferritin complexes.