Photoreceptor Protection by Adeno-Associated Virus–Mediated LEDGF Expression in the RCS Rat Model of Retinal Degeneration: Probing the Mechanism | Zendy

Dorit Raz-Prag | Zendy; Yong Zeng | Zendy; Paul A. Sieving | Zendy; Ronald A. Bush | Zendy

Open Access

Photoreceptor Protection by Adeno-Associated Virus–Mediated LEDGF Expression in the RCS Rat Model of Retinal Degeneration: Probing the Mechanism

Author(s) -

Dorit Raz-Prag,

Yong Zeng,

Paul A. Sieving,

Ronald A. Bush

Publication year - 2009

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.08-3153

Subject(s) - mechanism (biology) , retinal degeneration , degeneration (medical) , retinal , adeno associated virus , microbiology and biotechnology , chemistry , biology , ophthalmology , physics , medicine , vector (molecular biology) , gene , biochemistry , quantum mechanics , recombinant dna

Lens epithelium-derived growth factor (LEDGF) is upregulated in response to stress and enhances the survival of neurons in the retina and optic nerve, as well as a wide range of other cells, such as fibroblasts and keratinocytes. Photoreceptor protection was investigated in the RCS rat retinal degeneration model after Ledgf delivery with an adeno-associated virus (AAV) and the mechanism of protection explored.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research