Growth Factors Outside the PDGF Family Drive Experimental PVR | Zendy

Hetian Lei | Zendy; Gisela Velez | Zendy; Peter Hovland | Zendy; Tatsuo Hirose | Zendy; Debra G. Gilbertson | Zendy; Andrius Kazlauskas | Zendy

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Growth Factors Outside the PDGF Family Drive Experimental PVR

Author(s) -

Hetian Lei,

Gisela Velez,

Peter Hovland,

Tatsuo Hirose,

Debra G. Gilbertson,

Andrius Kazlauskas

Publication year - 2009

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.08-3042

Subject(s) - platelet derived growth factor receptor , business , medicine , growth factor , receptor

Proliferative vitreoretinopathy (PVR) is a recurring and problematic disease for which there is no pharmacologic treatment. Platelet-derived growth factor (PDGF) in the vitreous is associated with experimental and clinical PVR. Furthermore, PDGF receptors (PDGFRs) are present and activated in epiretinal membranes of patient donors, and they are essential for experimental PVR. These observations suggest that PVR arises at least in part from PDGF/PDGFR-driven events. The goal of this study was to determine whether PDGFs were a potential therapeutic target for PVR.

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