Complement Activation by Bisretinoid Constituents of RPE Lipofuscin | Zendy

Jilin Zhou | Zendy; So Ra Kim | Zendy; B. S. Westlund | Zendy; Janet R. Sparrow | Zendy

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Complement Activation by Bisretinoid Constituents of RPE Lipofuscin

Author(s) -

Jilin Zhou,

So Ra Kim,

B. S. Westlund,

Janet R. Sparrow

Publication year - 2009

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.08-2868

Subject(s) - lipofuscin , ic3b , retinal pigment epithelium , complement system , retinal , chemistry , alternative complement pathway , pigment , classical complement pathway , biochemistry , microbiology and biotechnology , biology , immunology , antibody , organic chemistry

Studies implicate activation of complement among the processes involved in the pathogenesis of age-related macular degeneration (AMD). Questions pertain to the trigger(s) responsible for the complement-associated events. The authors previously reported that photooxidation products of A2E can activate complement. Here they have further explored these events.

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