Control of Patterns of Corneal Innervation by Pax6 | Zendy

Lucy J. Leiper | Zendy; Jingxing Ou | Zendy; Petr Walczysko | Zendy; Romana Kucerova | Zendy; Derek N. Lavery | Zendy; John D. West | Zendy; J. Martin Collinson | Zendy

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Control of Patterns of Corneal Innervation by Pax6

Author(s) -

Lucy J. Leiper,

Jingxing Ou,

Petr Walczysko,

Romana Kucerova,

Derek N. Lavery,

John D. West,

J. Martin Collinson

Publication year - 2009

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.08-2812

Subject(s) - pax6 , corneal epithelium , biology , aniridia , epithelium , neurotrophic factors , neurotrophin , cornea , anatomy , pathology , microbiology and biotechnology , neuroscience , medicine , receptor , genetics , gene , transcription factor

Corneal nerves play essential roles in maintaining the ocular surface through provision of neurotrophic support, but genetic control of corneal innervation is poorly understood. The possibility of a neurotrophic failure in ocular surface disease associated with heterozygosity at the Pax6 locus (aniridia-related keratopathy [ARK]) was investigated.

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