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Glycogene Expression in Conjunctiva of Patients with Dry Eye: Downregulation of Notch Signaling
Author(s) -
Flavio Mantelli,
Lana Schaffer,
Reza Dana,
Steven R. Head,
Pablo Argu ̈eso
Publication year - 2009
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.08-2734
Subject(s) - notch signaling pathway , downregulation and upregulation , wnt signaling pathway , conjunctiva , biology , microbiology and biotechnology , glycoconjugate , notch proteins , epithelium , mucin , signal transduction , pathology , immunology , medicine , biochemistry , gene , genetics
Glycoconjugates regulate a variety of biological events in mucosal surfaces, such as differentiation of postmitotic epithelial cells and maintenance of the wet-surfaced phenotype. This study aimed to identify the repertoire of genes (glycogenes) involved in biosynthesis of glycoconjugates in conjunctiva of normal subjects and patients with dry eye.

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