Suppression of Retinal Neovascularization by Erythropoietin siRNA in a Mouse Model of Proliferative Retinopathy | Zendy

Jing Chen | Zendy; Kip M. Connor | Zendy; Christopher M. Aderman | Zendy; Keirnan Willett | Zendy; Oskar Aspegren | Zendy; Lois E.H. Smith | Zendy

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Suppression of Retinal Neovascularization by Erythropoietin siRNA in a Mouse Model of Proliferative Retinopathy

Author(s) -

Jing Chen,

Kip M. Connor,

Christopher M. Aderman,

Keirnan Willett,

Oskar Aspegren,

Lois E.H. Smith

Publication year - 2009

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.08-2521

Subject(s) - retinal , retina , neovascularization , erythropoietin , hypoxia (environmental) , retinopathy , angiogenesis , erythropoietin receptor , small interfering rna , biology , endocrinology , medicine , cancer research , chemistry , ophthalmology , cell culture , transfection , neuroscience , oxygen , organic chemistry , diabetes mellitus , genetics

Erythropoietin (EPO), an oxygen-regulated hormone stimulating erythrocyte production, was recently found to be critical for retinal angiogenesis. EPO mRNA expression levels in retina are highly elevated during the hypoxia-induced proliferation phase of retinopathy. The authors investigated the inhibition of retinal EPO mRNA expression with RNA interference as a potential strategy to suppress retinal neovascularization and to prevent proliferative retinopathy.

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