A Novel Rat Model with Obesity-Associated Retinal Degeneration | Zendy

G. Bhanuprakash Reddy | Zendy; Vidyullatha Vasireddy | Zendy; Md Nawajes A. Mandal | Zendy; T. Mrudula | Zendy; Xiaofei F. Wang | Zendy; Monica M. Jablonski | Zendy; Giridharan Nappanveettil | Zendy; Radha Ayyagari | Zendy

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A Novel Rat Model with Obesity-Associated Retinal Degeneration

Author(s) -

G. Bhanuprakash Reddy,

Vidyullatha Vasireddy,

Md Nawajes A. Mandal,

T. Mrudula,

Xiaofei F. Wang,

Monica M. Jablonski,

Giridharan Nappanveettil,

Radha Ayyagari

Publication year - 2009

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.08-2498

Subject(s) - retinal degeneration , retinal , retina , retinal regeneration , degeneration (medical) , biology , visual phototransduction , medicine , endocrinology , pathology , ophthalmology , neuroscience

A strong association between retinal degeneration and obesity has been shown in humans. However, the molecular basis of increased risk for retinal degeneration in obesity is unknown. Thus, an animal model with obesity and retinal degeneration would greatly aid the understanding of obesity-associated retinal degeneration. The retinal abnormalities in a novel rat model (WNIN-Ob) with spontaneously developed obesity are described.

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