Open AccessNonessential Role of β3 and β5 Integrin Subunits for Efficient Clearance of Cellular Debris after Light-Induced Photoreceptor Degeneration
Author(s) -
Sandrine Joly,
Marijana Samardzija,
Andreas Wenzel,
Markus Thiersch,
Christian Grimm
Publication year - 2009
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.08-2432
Subject(s) - integrin , degeneration (medical) , microbiology and biotechnology , chemistry , biophysics , biology , ophthalmology , medicine , biochemistry , receptor
During light-induced photoreceptor degeneration, large amounts of cellular debris are formed that must be cleared from the subretinal space. The integrins alphavbeta5 and alphavbeta3 are involved in the normal physiological process of phagocytosis in the retina. This study was conducted to investigate the question of whether the lack of beta5 and/or beta3 integrin subunits might influence the course of retinal degeneration and/or clearance of photoreceptor debris induced by acute exposure to light.