Open AccessInsulin Growth Factor 1 Receptor/PI3K/AKT Survival Pathway in Outer Segment Membranes of Rod Photoreceptors
Author(s) -
Ashok K. Dilly,
Raju V S Rajala
Publication year - 2008
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.08-2286
Subject(s) - pi3k/akt/mtor pathway , microbiology and biotechnology , insulin like growth factor , membrane , receptor , protein kinase b , biology , growth factor , chemistry , signal transduction , biochemistry
The authors previously reported that physiological light induces the tyrosine phosphorylation of insulin receptors (IRs), which leads to the activation of the phosphoinositide 3-kinase (PI3K) and Akt (serine/threonine protein kinase B) survival pathway in rod photoreceptor cells. Tissue-specific deletion of IRs from photoreceptors resulted in stress-induced photoreceptor degeneration. Insulin growth factor 1 receptor (IGF-1R) is highly related in sequence and structure to the IR and shares 70% sequence identity overall and 84% identity within the tyrosine kinase domain. The role of IGF-1R in photoreceptor function is unknown. In this study the authors examined IGF-1R signaling in rod outer segment (ROS) membranes.