Hypermucoviscosity as a Virulence Factor in ExperimentalKlebsiella pneumoniaeEndophthalmitis | Zendy

Brandt Wiskur | Zendy; Jonathan J. Hunt | Zendy; Michelle C. Callegan | Zendy

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Hypermucoviscosity as a Virulence Factor in ExperimentalKlebsiella pneumoniaeEndophthalmitis

Author(s) -

Brandt Wiskur,

Jonathan J. Hunt,

Michelle C. Callegan

Publication year - 2008

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.08-2276

Subject(s) - klebsiella pneumoniae , endophthalmitis , streptococcus pneumoniae , medicine , microbiology and biotechnology , virulence , bacteremia , strain (injury) , eye disease , biology , ophthalmology , escherichia coli , gene , biochemistry , antibiotics

Klebsiella pneumoniae is a common cause of endogenous bacterial endophthalmitis, a disease that frequently results in a poor visual outcome. Hypermucoviscosity has been identified as a virulence factor among clinical bacteremia isolates of K. pneumoniae. In this study, an experimental murine model of K. pneumoniae endophthalmitis was established, and the role of hypermucoviscosity in its pathogenesis was analyzed.

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