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HMG-CoA Reductase Inhibitors (Statin) Prevents Retinal Neovascularization in a Model of Oxygen-Induced Retinopathy
Author(s) -
Manuela Bartoli,
Mohamed AlShabrawey,
M. Labazi,
M. Ali Behzadian,
Mohamed Istanboli,
Azza B. ElRemessy,
Robert W. Caldwell,
Dennis M. Marcus,
Ruth B. Caldwell
Publication year - 2009
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.08-2158
Subject(s) - neovascularization , statin , retinal , pharmacology , fluvastatin , medicine , lipid peroxidation , ischemia , oxidative stress , angiogenesis , ophthalmology , simvastatin
Retinal neovascularization (RNV) is a primary cause of blindness and involves the dysfunction of retinal capillaries. Recent studies have emphasized the beneficial effects of inhibitors of HMG-CoA reductase (statins) in preventing vascular dysfunction. In the present study, the authors characterized the therapeutic effects of statins on RNV.

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