Open AccessAmyloid-β Deposits Lead to Retinal Degeneration in a Mouse Model of Alzheimer Disease
Author(s) -
Allison Ning,
Jing Cui,
Eleanor To,
Karen H. Ashe,
Joanne A. Matsubara
Publication year - 2008
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.08-1849
Subject(s) - retina , genetically modified mouse , amyloid precursor protein , biology , amyloid (mycology) , presenilin , amyloid beta , outer nuclear layer , pathology , neurodegeneration , ganglion cell layer , alzheimer's disease , retinal ganglion cell , retinal , microbiology and biotechnology , transgene , neuroscience , medicine , biochemistry , disease , gene
To compare the temporal and spatial expression patterns of amyloid precursor protein (APP), amyloid-beta deposits, inflammatory chemokines, and apoptosis in the retina of a mouse model of Alzheimer disease (AD).