Identification of Candidate Klf4 Target Genes Reveals the Molecular Basis of the Diverse Regulatory Roles of Klf4 in the Mouse Cornea | Zendy

Shivalingappa K. Swamynathan | Zendy; Janine Davis | Zendy; Joram Piatigorsky | Zendy

Open Access

Identification of Candidate Klf4 Target Genes Reveals the Molecular Basis of the Diverse Regulatory Roles of Klf4 in the Mouse Cornea

Author(s) -

Shivalingappa K. Swamynathan,

Janine Davis,

Joram Piatigorsky

Publication year - 2008

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.08-1811

Subject(s) - klf4 , cornea , biology , downregulation and upregulation , filaggrin , keratin 14 , microbiology and biotechnology , gene , genetics , transcription factor , immunology , transgene , genetically modified mouse , sox2 , atopic dermatitis , neuroscience

Krüppel-like factor 4 (Klf4) plays a crucial role in the development and maintenance of the mouse cornea. In the current study, wild-type (WT) and Klf4-conditional null (Klf4CN) corneal gene expression patterns were examined, to gain understanding of the molecular basis of the Klf4CN corneal phenotype.

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