Involvement of OA1, an Intracellular GPCR, and Gαi3, Its Binding Protein, in Melanosomal Biogenesis and Optic Pathway Formation | Zendy

Alejandra Young | Zendy; Elisabeth B. Powelson | Zendy; Irene E. Whitney | Zendy; Mary A. Raven | Zendy; Steven Nusinowitz | Zendy; Meisheng Jiang | Zendy; Lutz Birnbaumer | Zendy; Benjamin E. Reese | Zendy; Debora B. Farber | Zendy

Open Access

Involvement of OA1, an Intracellular GPCR, and Gαi3, Its Binding Protein, in Melanosomal Biogenesis and Optic Pathway Formation

Author(s) -

Alejandra Young,

Elisabeth B. Powelson,

Irene E. Whitney,

Mary A. Raven,

Steven Nusinowitz,

Meisheng Jiang,

Lutz Birnbaumer,

Benjamin E. Reese,

Debora B. Farber

Publication year - 2008

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.08-1806

Subject(s) - melanosome , biology , microbiology and biotechnology , heterotrimeric g protein , retinal pigment epithelium , retina , biogenesis , g protein coupled receptor , protein subunit , signal transduction , g protein , genetics , neuroscience , gene , melanin

Ocular albinism type 1 (OA1) is characterized by abnormalities in retinal pigment epithelium (RPE) melanosomes and misrouting of optic axons. The OA1 gene encodes a G-protein-coupled receptor (GPCR) that coimmunoprecipitates with the G alpha i-subunit of heterotrimeric G-proteins from human melanocyte extracts. This study was undertaken to test whether one of the G alpha i proteins, G alpha i3, signals in the same pathway as OA1 to regulate melanosome biogenesis and axonal growth through the optic chiasm.

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