Suppression of Activation and Induction of Apoptosis in RAW264.7 Cells by Amniotic Membrane Extract | Zendy

Hua He | Zendy; Wei Li | Zendy; SzuYu Chen | Zendy; Shan Zhang | Zendy; YingTing Chen | Zendy; Yasutaka Hayashida | Zendy; Yingting Zhu | Zendy; Scheffer C.G. Tseng | Zendy

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Suppression of Activation and Induction of Apoptosis in RAW264.7 Cells by Amniotic Membrane Extract

Author(s) -

Hua He,

Wei Li,

SzuYu Chen,

Shan Zhang,

YingTing Chen,

Yasutaka Hayashida,

Yingting Zhu,

Scheffer C.G. Tseng

Publication year - 2008

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.08-1781

Subject(s) - apoptosis , chemistry , microbiology and biotechnology , membrane , andrology , biology , medicine , biochemistry

Macrophages play a pivotal role in initiating, maintaining, and resolving host inflammatory/immune responses but may cause recalcitrant inflammation and tissue damage if not controlled. Clinically, amniotic membrane (AM) transplantation suppresses inflammation in ocular surface reconstruction. Experimentally, the authors and others have reported that AM facilitates macrophage apoptosis. However, it remains unclear whether such anti-inflammatory activity is retained in AM extract (AME).

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